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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '504d6fe98e9df94856dddd006511943172063998d76f7b883dc82427aaea0291' 
  AND token = 'VxBHsAEM2coswN8DEgEcU+B1KJzLI1seWoa6s0Z8wr8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}