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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ce335667d8148427e6b6c5ed8c9644c10236e2db92161ce13f7702807775ec1' 
  AND token = 'aO2rH+CMQwMwXnsXBmdskzl/U3QiXtO5QtDWVbdw6XQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}