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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '378ca3e63a32bf375cf6fc3be09a43c284d4fa18ca060da177f06c7c2ae5dcf8' 
  AND token = 'C5yPOzkDF8Qi9G8EQnHB9oLh4UmGC6Q0m8aw4xB6kN8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}