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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '666389141a71e01d11b1829c6a821a46ba1a62a55481f0b4f85e278cdb2396dc' 
  AND token = 'uYe0IjFvytmJ/UxtJIZ6SEHdDvok4ip1Ec+1oz09Sr0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}