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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8b4993a816dce99a991f89bed887c8526cc24dbf47dd60eb06185623d31a148' 
  AND token = 'quhFiwgK/3N0bRSX+janWK3XBz6A5nXtck902sxPIDo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}