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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a59c7064197abbf684ef467418f7635b1955d231a0b91a95e8b6fdc82098a48' 
  AND token = 'p5w2RcWU1zdWO3Fhj6CKw+OqVbQiH5rMgkr93y8yhtM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}