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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '181ae1b89fcaf09549daae315d61a1dc794403cea5651ac8b131811e9764121e' 
  AND token = 'CW1eRqtEcHwmqj5pEEKI/vaRiFIqPi02AOe5R/S00KU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}