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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0163eaf5ef353962f168cf51aba16a44d429c74ce199cf2503b55e54803e15b4' 
  AND token = 'Rb0aNN45M5QkaA0ZIVOcmQe4lq+5K7TEigYDdbcwOrk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}