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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b60adfa0c62c045a56d1bf63bbc30f07639b68a9805c8673dbbc41d6f1e4741' 
  AND token = 'QF3P4j5a7ds4ZUGKahNgmjYpj4153dBOPmxuvyGv2EM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}