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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49086101abf166da11e6d048eb000c653cfc356263b182ff4fec4b867f93e98f' 
  AND token = 'I02YdNaiSP30EYYo8/qQeUAkKvE/++Oo9oPff3eK0aU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}