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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd2b33e22f9fb873e85a710cf94b620e8b7894431f34fd4f36532f606c416f3a7' 
  AND token = 'dAHD6X3xVxiIaSSOjxj00cXp+ZGWC7grPF88XITxwHs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}