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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd49a269e9af9e70ddb4aba14fbb457595e17bd73979e514b1df7eb1af41cb208' 
  AND token = 'oGec+SdTEVMnl9mTQNMMzyX9It5t+cNDn00p9ZPwBzw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}