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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43e3ffda121074eed806f82e0c3a7acfa5ede06c4d4fa7ed13129b5e27c3f43e' 
  AND token = '3c/PV1HlPB4efVOSabOLSNwdRIflOPB+xCn5sz+o2JE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}