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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1de249ee1d6e0e5f3bd1a35774cc532d0baf03fdb74125df724190aaf5053a1f' 
  AND token = 'oihbxpdaAvoKUbYCe5tw8haOX6L9xWhglnkh914EJfI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}