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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ded5c6fff14fe0b9a7df78950a22f401e6f39e9c9f228c21007266c6425026' 
  AND token = 'KCAFhaIR0/JlEdhn7vLN0cEH3E9DDTLYzi+uSCsWVAE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}