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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c0b216243852828c97a09f0bd08947e314a59970d1ca2d3b655cbe72d5acfb3d' 
  AND token = 'eoc187KQQQbAsSfXPAncx+nvaIn65YrRzYLVXGlWCIs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}