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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66b5c4829d1b73c05ffb5a20d2e81ae248c3a16d98c01808f82dd626a9b11150' 
  AND token = 'dXfR1FWFjgh7N7yHxKLRKk7vlc3TEyoCUA+VtwTbhhg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}