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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd2e16ebc93faf2f241ef8fb4e971cda1d355b0fd110100f649574cf0411d8cd5' 
  AND token = '+mEIqVF1s1hkQSa5j9eBcaOJXM+zs7VRdUFOINKTM6Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}