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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05154fe366d87bbec51986928db2a64a130bc52387d6b428220b35126c569520' 
  AND token = 'ENs+eKV0zgHVC10ZAV9fk8aIVpdwzDuU7sMrPVtDLwY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}