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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8bb96e8fb0b967164617d3c687b2a0012596cbed7e32be2cd1c1abf3015d9d0a' 
  AND token = 'rJMV2ThSKC0NrH1xlC3d9dnrV7aRjKmpcNgGOmz4ap8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}