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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2cada9d0e76ac29fab394ffb291214d8a1507b1d308c238d557a5ccb0a4973ed' 
  AND token = 'fuYvZ4EVf4IqgXjY4q+PkO4nkNeAnSB1A8k6lgTm5Ik=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}