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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '457154b414691dbb9ceb65b1ba536dabc5308a55292b903da3e2b2d7725810a2' 
  AND token = 'c9upjAEW2DEBOhMx54cG6RxLrLfjrdUfy714njCVPrw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}