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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8f9b2435885a3d6afc342177a7343dad0472ea4dd456bdcc1823e1fcdfcb781' 
  AND token = 'E/emZ9/KWixibdJkXmYaWhc9ZiqPHkAOESnB6dZ4WxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}