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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64dcf276f1a0cec2021f2388057b7db4f132999de6acad3dc6e3146118c622e0' 
  AND token = '7gDNzbEY4qeqWW/zcpPMfbrGDl8NaVOQCEtUTjSmDqY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}