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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3224f4a8bc66c4defbb94d5650acfd722f6152f925ad2f04cc92fd9eac48548d' 
  AND token = 'MO/ow2vmTZiTd9kPho89G0x7qgYRaUtLaVE5gfOBXag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}