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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d17a08e7bbcb8f5f5a8346090535cc337750432ef60fc32711ee3c4e620c373' 
  AND token = 'cATM2FNkopu2dPbm0yNFgYr3/+sIQxcpvhNThblTWd0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}