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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '77b46d7fca6b19025187e6d9bd8d1fa2bea4b6c5480265037f232654b1109de4' 
  AND token = '8YUiGht1M9BIFV04XMGAAZdIxUY4WWVHL5W+HIhdSjI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}