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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a3b7fe7f0a0f8547825a09f2448263ad51d840692d0868be1e2037d91f049676' 
  AND token = '+rExi2TFBCA1fybEgPdFcInITemS7SCBIvVb4WInbuM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}