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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0253ca19e142be20c627d73fc410c7e3f0e675ec5634a195b6ddef378b1fa421' 
  AND token = 'qFW+hxTrRP+Kcktb3y7cusLOb48fm29An/hubg67wnQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}