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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16dea509ae9a0bf9ee09445bf05ed64bf2b52ca313205abb974d4f7b6ced6513' 
  AND token = 'HioyFWKwQ/xuy1D/uD4H7UQOiZtKxEsXsu5V3JJjO58=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}