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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e9a1268a3bec94b14203369a36fb14f4045bb27f25bc735de6dc5e30e2edcbd6' 
  AND token = 'f+tkRGZiiCKPJTLRArsUCc/C6/xWwNNiuTY0yyfxnGk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}