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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c61f22b06aa0228dbaefcad563ac65a6d3b5c857e16ca2bf2d422860bc8b425' 
  AND token = 'yEO+gvZKQqwXr4GW8GHL2rUzJTgihn35NRqEs9xwlCE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}