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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '857f76e1d78202d9d2aa1bf906bab721c2ebec1e37e7fd5b01916224ecc025ec' 
  AND token = 'AwRNVW27KhMIZlpAlW4P6zlMv4+ZulrCq0+Ybmyx3EY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}