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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c760048e293feccce50845ff64205cfd9415f8d1d35c409836710c521af376b' 
  AND token = 'hUE3h4ft1u9xYKatYfDDkRnOKnN4fy15vEpknaWpBuA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}