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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2491a71004370514da0d99715a96035da5b5b47e803c4004231f513f510b8eda' 
  AND token = 'UF4QIJw2ArJZmgE37hIEVwjzjxtUl7W2TmuLaBwGPh8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}