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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e3af57441daf631b4787763854568ee643a7bc760f385e96af273d02ef0a53e' 
  AND token = '067ZTnMy9PWoC8KON5MeMQ0UyzP+DIC8vrQ+tWAIdZ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}