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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '725f908cd40d28990a2487a5d5acb41b12876fc475de9957aa6c8e535d92e1bf' 
  AND token = 'cXp1VMqq7rVSVMo8FdtnncXsx42urxZPSTvFOXtwZQI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}