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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43403e7ce51542b0b1f47dbd8bb17d1e6a0a4cd0027f96c921732041a9085492' 
  AND token = 'pIX8EoiLCn5aLw2ULi4wVJlH8RyVMkRcD7Z+gFlPAa8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}