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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e729e6410ba4f260fec2feeedf465c2bad96446bfa7803b4b33198c09e2c370' 
  AND token = 'p8bc7JW3VhXrXWiY5IIrrQbm2RmAaiTPZWTQFFmGq74=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}