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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '387da78db5de7ff273f5a152a07ea95a1f63298d879ad3cce7f977f87ab9e3ce' 
  AND token = 'FOS3SU8wp+uP+h95Xxf0NuLtPEqVbI6LVE1sXwx39WQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}