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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4bd02c48b3322089d0d46cf8c338bad261be12d9726e7e022b97a12accae6df1' 
  AND token = 'tuQTHUcqYYT2k0X81B+t6yo+xdS30M3vmGDjTBOrrqM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}