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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c5ba5b037c76077eef3b17a325201d3ff7a1413d798e4237891a6591a455fc2' 
  AND token = '+ommg7Xow60TISliS/m0F4rOQDQWP+PRD4z6YXzAIcI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}