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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9cef5dc0ab973046e6104930330bc59d1c8b6c2983d84d39afec48193651f7e8' 
  AND token = 'iqQUsr78B4SeamWnXrm38Bu1UYoE28H11RFDS/xWnD4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}