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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65243102e5c5547ec075cd5fd5bf9e7cdf3894882b6c4188c27871210b51830a' 
  AND token = 'ruwc5QS78g+NENAvl8yjereWClSnXwyp8yyy7n3sYS0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}