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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22cf11f855006fbb36c0b63470a8b5a07188a71e75f8ecb6e7146427fb275a29' 
  AND token = 'tmw3J6QtSntxPx7r8lTcxV8/3uDbJrGjJuthMjVPLg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}