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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7505b5d46e62aea2e8258da6e7068198a654ca3e7365973695d85e800982138c' 
  AND token = 'o2dPFM+3d2zk8RgOnCFT+WaCc/FuSinVJYCJeRCdURY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}