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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '581e94082f9c3edbd244ceb56beffe6fd1de644fb4e7b276f8fbbe6f250e45df' 
  AND token = 'asds55MNi5rIbZSYcUSLC+lH6IB0aMowtKRIk/NJFAU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}