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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4678ff3d42003f3d99e2f0f6b9a8daade729e5864bf91e1a175db6f3f2a8d155' 
  AND token = 'fqw0pA9c/Vbw+a7bAdbQf4SwVF13O0uoeM/Tkfh8JAE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}