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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b8c3f35d80c962a2156bf55e48a1f6f2cec39c0f427a02c8b3d272fe5535336' 
  AND token = 'F3Kpb2Ap6xUaTdO3wI6L5kBs4txmIw1j7xLrSS3AYUI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}