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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e16dcf472a2cb24db0fc7de2d5fbf2979292b6c1bae7bc4218d838e22252a865' 
  AND token = 'j/DUSBG8sBPhwCPsAREHEY7fDmGT2rT2uGFZ+M1dQU8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}